GLP-1 Weight Loss Medications

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GLP-1 weight loss medications should only be used in people 18 and over with obesity (BMI >= 30). They may also be used if the BMI is >= 27 with a compelling related medical problem, like high blood pressure or high cholesterol. GLP-1 weight loss medications should not be used for purely cosmetic weight loss.

In addition, GLP-1 weight loss medications should not be used in the following situations:

1. Personal or family history of medullary thyroid carcinoma, or multiple endocrine neoplasia type 2.
2. History of pancreatitis.
3. Known allergy to GLP-1 weight loss medication ingredients.
4. May cause fetal harm – discontinuation instructions vary by GLP-1 weight loss medication.
5. Do not use GLP-1 weight loss medications while breastfeeding.
6. Some GLP-1 weight loss medications including Wegovy and Saxenda are indicated down to age 12.

Pricing and options are continually changing. As of 11/18/2024, here are some of the options for GLP-1 Weight loss Medications are as follows:

• If you have insurance coverage, usually $0 – $100 per month
• If you do not have insurance coverage but qualify for the coupon, $650 per month
• Cash Pay: Lilly offers Zepbound in Vials for $399 (2.5 mg dose) and $549 (5.0 mg dose)
• There are many other cost effective ways to use GLP-1 weight loss medications at a much lower price point including: Canadian suppliers, dose-splitting, and more. Our providers can almost always find a cost effective solution for you!

The GLP-1 weight loss medication injections do not hurt.

The injections are done by yourself at home once a week (except liraglutide, which is daily).

Most side effects are mild to moderate. They may include: nausea, vomiting, diarrhea, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distention, eructation (burping), hypoglycemia in patients with diabetes, flatulence, gastroenteritis, gastroesophageal reflux disease, and nasopharyngitis.

If the missed dose will be done more than 48 hours before the next regularly scheduled dose, then administer as soon as possible. If less than 48 hours before the next regularly scheduled dose, you may wait and resume on your regularly scheduled day. If you miss more than 2 doses, talk with your provider about possibly resuming at a lower dose to lower the chance of side effects.

GLP-1 weight loss medication treatments don’t take the weight off by themselves – they help control your appetite so you can eat a lower calorie food plan without feeling hungry. However, if you don’t eat a healthy diet and get regular physical activity, a lot of the weight lost will be muscle. For this reason, it is important to review your eating plan and physical activity plan with your CNC staff. Further, we recommend monitoring body composition on our seca medical body composition analyzer so we can track your fat vs. lean loss.

1. We recommend starting your GLP-1 on a Sunday or Monday evening. Then, if there are side effects, you can call us at the office at (303) 750-9454 to assist you.
2. Avoid eating out the first couple days after your first shot at each new dose..
3. Avoid high-fat or high-carb foods the first couple days after your first shot at each new dose.
4. Careful with Alcohol – it may seem a lot stronger than you remember.
5. To avoid nausea, eat something immediately when you wake up, even if you are nauseous. We’ve found a protein drink can really settle down the stomach. Even a glass of water can help reduce or prevent nausea.
6. Eat frequent small meals throughout the day the first couple days after the injection. Choose small amounts of proteins and vegetables.
7. If the injection site hurts, it could be from injecting the medication while it is cold – consider allowing your medication to come to room temperature before the injection.
8. See a provider or dietitian at CNC each month to customize your plan, figure out your best dose, and help you maximize your results.
9. Do not stop your GLP-1 medication without discussing this with your CNC provider – obesity is a chronic health problem, and we usually use these medications long-term.

https://youtu.be/f9E5RG-xQxI

If your GLP-1 medication comes in a vial, click here to watch Jamie Shriver, PA-C, show how to safely draw up and inject the correct dose.

Important Safety Information about GLP-1 Weight Loss Medications

GLP-1 may cause serious side effects, including:

• Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, GLP-1 medicines caused thyroid tumors, including thyroid cancer. It is not known if GLP-1 will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not use GLP-1 if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Do not use GLP-1 if you have had a serious allergic reaction to semaglutide or tirzepatide or any of the ingredients in GLP-1.

Before using GLP-1, tell your healthcare provider if you have any other medical conditions, including if you:

• have or have had problems with your pancreas or kidneys
• have type 2 diabetes and a history of diabetic retinopathy
• have or have had depression, suicidal thoughts, or mental health issues
• are pregnant or plan to become pregnant. GLP-1 may harm your unborn baby. You should stop using GLP-1 2 months before you plan to become pregnant (semaglutide products), or if pregnancy is detected (tirzepatide products).
• are breastfeeding or plan to breastfeed. It is not known if GLP-1 passes into your breast milk
• Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. GLP-1 may affect the way some medicines work and some medicines may affect the way GLP-1 works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin.
• GLP-1 slows stomach emptying and can affect medicines that need to pass through the stomach quickly.

GLP-1 may cause serious side effects, including:

• inflammation of your pancreas (pancreatitis). Stop using GLP-1 and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back
• gallbladder problems. GLP-1 may cause gallbladder problems, including gallstones. Some gallstones may need surgery. Call your healthcare provider if you have symptoms, such as pain in your upper stomach (abdomen), fever, yellowing of the skin or eyes (jaundice), or clay- colored stools
• increased risk of low blood sugar (hypoglycemia), especially those who also take medicines for diabetes such as insulin or sulfonylureas. This can be a serious side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar and check your blood sugar before you start and while you take GLP-1. Signs and symptoms of low blood sugar may include dizziness or light-headedness, blurred vision, anxiety, irritability or mood changes, sweating, slurred speech, hunger, confusion or drowsiness, shakiness, weakness, headache, fast heartbeat, or feeling jittery
• kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration
• serious allergic reactions. Stop using GLP-1 and get medical help right away, if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat
• change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with GLP-1
• increased heart rate. GLP-1 can increase your heart rate while you are at rest. Tell your healthcare provider if you feel your heart racing or pounding in your chest and it lasts for several minutes
• depression or thoughts of suicide. You should pay attention to any mental changes, especially sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you
• Alert your healthcare provider if you are planning to have surgery or procedures that require deep sedation

The most common side effects of GLP-1 may include: nausea, diarrhea, vomiting, constipation, stomach (abdomen) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, heartburn, and runny nose or sore throat.

This information is intended for your private use only.