Archives Research Updates

CagriSema: Why Lean Mass May Be the Real Story

Syringe injecting through skin with two hormonal pathways illustrated (GLP-1 and amylin), representing CagriSema's combination weight-loss therapy mechanism

The 22.7% weight loss number doesn’t tell the whole story. CagriSema — Novo Nordisk’s combination of semaglutide plus cagrilintide, an amylin analogue — posted that figure in REDEFINE 1. It’s impressive. It’s also incomplete. Because the more interesting question isn’t…

Retatrutide TRIUMPH-2/3: Up to 22.6% Weight Loss | Denver

Illustration of a person with obesity and type 2 diabetes or cardiovascular disease achieving significant weight loss through retatrutide triple agonist treatment, with data visualization showing 20-23% weight reduction and improved cardiometabolic markers including reduced triglycerides, cholesterol, blood pressure, and inflammation.

Eli Lilly’s retatrutide just got more interesting. Two new Phase 3 trials—TRIUMPH-2 and TRIUMPH-3—delivered results that matter for the patients I see most: people with obesity complicated by type 2 diabetes or established cardiovascular disease. The triple GIP/GLP-1/glucagon agonist achieved…

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